Cooney M K, Kenny G E, Tam R, Fox J P
Infect Immun. 1973 Mar;7(3):335-40. doi: 10.1128/iai.7.3.335-340.1973.
Antisera produced in rabbits to 37 rhinovirus (RV) types have been examined for antibody to the 36 corresponding heterologous types. Reciprocal neutralization was noted between RV types 2 and 49 and RV types 13 and 41. Five additional monotypic rhinoviral rabbit antisera neutralized one heterologous rhinovirus. Neutralizing antibody titers against heterologous RV serotypes were similar to those shown in the RV 1A, 1B and RV 9, 32 reciprocal cross-reactions, and would not be expected to result in false identification of serotypes. Comparison of neutralizing antibody titers and neutralization rate constants in serial serum specimens of immunized rabbits showed that antibody response to the immunizing RV type and the cross-reacting type followed a similar time pattern.
已检测用兔制备的针对37种鼻病毒(RV)型别的抗血清,以寻找针对36种相应异源型别的抗体。在RV 2型和49型以及RV 13型和41型之间观察到相互中和作用。另外五种单型鼻病毒兔抗血清中和了一种异源鼻病毒。针对异源RV血清型的中和抗体滴度与RV 1A、1B以及RV 9、32相互交叉反应中显示的滴度相似,预计不会导致血清型的错误鉴定。对免疫兔的系列血清标本中的中和抗体滴度和中和速率常数进行比较表明,对免疫RV型别和交叉反应型别的抗体反应遵循相似的时间模式。