蛋白质中的成核、快速折叠及球状链内区域
Nucleation, rapid folding, and globular intrachain regions in proteins.
作者信息
Wetlaufer D B
出版信息
Proc Natl Acad Sci U S A. 1973 Mar;70(3):697-701. doi: 10.1073/pnas.70.3.697.
Abstract
Distinct structural regions have been found in several globular proteins composed of single polypeptide chains. The existence of such regions and the continuity of peptide chain within them, coupled with kinetic arguments, suggests that the early stages of three-dimensional structure formation (nucleation) occur independently in separate parts of these molecules. A nucleus can grow rapidly by adding peptide chain segments that are close to the nucleus in aminoacid sequence. Such a process would generate three-dimensional (native) protein structures that contain separate regions of continuous peptide chain. Possible means of testing this hypothesis are discussed.
摘要
在由单条多肽链组成的几种球状蛋白质中发现了不同的结构区域。这些区域的存在以及其中肽链的连续性，再加上动力学方面的论据，表明三维结构形成的早期阶段（成核）在这些分子的不同部分独立发生。一个核可以通过添加在氨基酸序列上与该核相近的肽链片段而迅速生长。这样一个过程将产生包含连续肽链的不同区域的三维（天然）蛋白质结构。文中讨论了检验这一假设的可能方法。
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On the Structure of Native, Denatured, and Coagulated Proteins.关于天然、变性和凝固蛋白质的结构
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