驱虫药噻嘧啶的一些药理作用。
Some pharmacological effects of the nematocide, morantel.
作者信息
Bamgbose S O, Marquis V O, Salako L A
出版信息
Br J Pharmacol. 1973 Jan;47(1):117-23. doi: 10.1111/j.1476-5381.1973.tb08164.x.
Abstract
- In isolated nerve-muscle preparations as well as in nerve-muscle preparations in intact anaesthetized animals, morantel exhibited neuromuscular blocking properties similar to those of depolarizing blockers. The drug also caused spastic paralysis of 3 day-old chicks and contracture of the isolated toad rectus abdominis muscle.2. Morantel caused contraction of the guinea-pig and rabbit isolated small intestine. This effect was antagonized by atropine and hexamethonium.3. Morantel caused an increase in the blood pressure of the anaesthetized rat and cat and contraction of the nictitating membrane of the anaesthetized cat. These effects were antagonized by hexamethonium.4. It was concluded that morantel (like the related compound pyrantel) has acetylcholine-like action and that its structure is consistent with such action.
摘要
在离体神经肌肉标本以及完整麻醉动物的神经肌肉标本中，噻嘧啶表现出与去极化阻滞剂相似的神经肌肉阻滞特性。该药物还导致3日龄雏鸡发生痉挛性麻痹以及离体蟾蜍腹直肌挛缩。
噻嘧啶引起豚鼠和兔离体小肠收缩。这种作用可被阿托品和六甲铵拮抗。
噻嘧啶使麻醉大鼠和猫的血压升高，并使麻醉猫的瞬膜收缩。这些作用可被六甲铵拮抗。
得出的结论是，噻嘧啶（与相关化合物噻嘧啶类似）具有乙酰胆碱样作用，且其结构与这种作用相符。
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