Walters M L, Stanley N F, Dawkins R L, Alpers M P
Br J Exp Pathol. 1973 Jun;54(3):329-45.
Following acute neonatal infection with reovirus 3 in mice of Prince Henry, Balb/c and C57B1 strains, 8·7% of mice surviving to 22 days developed a syndrome of chronic jaundice and runting. In 1·6% the syndrome persisted beyond 60 days, enabling the immunological status of mice suffering from the persisting chronic syndrome to be assessed. Immune responses, both humoral and cell mediated, were either normal or enhanced. Serum immunoglobulin levels were raised. Anti-smooth muscle antibody was commonly found beyond 100 days of age and there was a low titre of haemagglutinating autoantibody; however, no evidence to suggest an initiating autoaggressive pathogenesis of the syndrome was found. The syndrome closely resembles active chronic hepatitis in man. The initial acute infection with reovirus 3 is essential for the production of the persisting chronic disease, but neither infectious virus nor viral antigen could be detected at this stage.
在用3型呼肠孤病毒对亨利王子株、Balb/c株和C57B1株小鼠进行急性新生期感染后，存活至22天的小鼠中有8.7%出现了慢性黄疸和发育迟缓综合征。1.6%的小鼠该综合征持续超过60天，从而能够评估患有持续性慢性综合征小鼠的免疫状态。体液免疫和细胞介导免疫反应均正常或增强。血清免疫球蛋白水平升高。抗平滑肌抗体在100日龄后常见，且血凝自身抗体滴度较低；然而，未发现表明该综合征存在自身攻击性发病机制的证据。该综合征与人类的活动性慢性肝炎极为相似。3型呼肠孤病毒的初始急性感染对于持续性慢性疾病的产生至关重要，但在此阶段既检测不到感染性病毒，也检测不到病毒抗原。
