志愿者鼻病毒感染中的血凝抑制试验
Hemagglutination-inhibition test in rhinovirus infections of volunteers.
作者信息
Reed S E, Hall T S
出版信息
Infect Immun. 1973 Jul;8(1):1-3. doi: 10.1128/iai.8.1.1-3.1973.
Abstract
The hemagglutination-inhibition (HI) test for antirhinovirus antibody was carried out on paired sera from volunteers inoculated with rhinovirus type 3 or type 4 (RV4). The HI test gave results which paralleled the neutralization test and was at least as sensitive as a microneutralization method for detection of serotype-specific antibody. Although high levels of HI antibody in the serum were associated with protection from infection, in the case of RV4 low serum HI antibody levels did not necessarily imply susceptibility to challenge with small doses of virus. HI activity could be measured in concentrated nasal-washing fluids, and this antibody also seemed relevant to protection against infection.
摘要
对接种了3型或4型鼻病毒（RV4）的志愿者的配对血清进行了抗鼻病毒抗体的血凝抑制（HI）试验。HI试验结果与中和试验结果相似，并且在检测血清型特异性抗体方面至少与微量中和法一样灵敏。虽然血清中高水平的HI抗体与预防感染有关，但在RV4的情况下，血清HI抗体水平低并不一定意味着对小剂量病毒攻击易感。可在浓缩的鼻腔冲洗液中检测到HI活性，并且这种抗体似乎也与预防感染有关。
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