McGinty F, Delides G, Harrison D
Gut. 1973 Jun;14(6):502-5. doi: 10.1136/gut.14.6.502.
The activities of 13 enzymes in 40 carcinomas of the large bowel have been studied using histochemical techniques. Five enzymes-non-specific esterase, monoamine oxidase, succinate dehydrogenase, cytochrome oxidase, and acid phosphatase-commonly show much less activity in the tumours than in adjacent normal colon. The tumours have been classified based upon the number of enzymes which show marked reduction in activity in each tumour (types 1-5). The enzyme histochemical type and the size of the tumours have been jointly correlated with the presence of lymph node metastasis. Small type 1 or 2 tumours do not appear to be associated with metastatic disease. Small type 5 tumours were commonly associated with secondary carcinoma in the lymph nodes. Large tumours (greater than 25 sq cm surface area) of any histochemical type were frequently associated with lymph node metastasis. Discussion of the possible reasons for these findings and their clinical significance is presented.
利用组织化学技术研究了40例大肠癌中13种酶的活性。五种酶——非特异性酯酶、单胺氧化酶、琥珀酸脱氢酶、细胞色素氧化酶和酸性磷酸酶——通常在肿瘤中的活性远低于相邻的正常结肠。根据每个肿瘤中活性显著降低的酶的数量（1 - 5型）对肿瘤进行了分类。酶组织化学类型和肿瘤大小与淋巴结转移的存在情况进行了联合关联分析。小型1型或2型肿瘤似乎与转移性疾病无关。小型5型肿瘤通常与淋巴结继发性癌有关。对这些发现的可能原因及其临床意义进行了讨论。
