在激素反应性肿瘤的细胞质中证实存在糖皮质激素激素-受体复合物。
Demonstration of a glucocorticoid hormone-receptor complex in the cytoplasm of a hormone-responsive tumour.
作者信息
Gardner D G, Wittliff J L
出版信息
Br J Cancer. 1973 Jun;27(6):441-4. doi: 10.1038/bjc.1973.55.
Abstract
Specific substances binding [(3)H]-triamcinolone acetonide have been demonstrated in the cytoplasmic fraction of the R3230AC mammary carcinoma using sucrose gradient centrifugation. These receptors, which exhibit sedimentation coefficients of 8-9 Svedberg units, are relatively specific for glucocorticoid ligands and possess a high affinity for triamcinolone acetonide (K(d)∼7 × 10(-8) mol/1).
摘要
利用蔗糖梯度离心法已在R3230AC乳腺癌的细胞质部分中证实了能结合[³H] - 曲安奈德的特定物质。这些受体的沉降系数为8 - 9斯维德伯格单位，对糖皮质激素配体具有相对特异性，并且对曲安奈德具有高亲和力（解离常数K(d)约为7×10⁻⁸摩尔/升）。
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[Current status in the treatment of breast cancer. I. Endocrine management--change of concepts and outlook for the future (author's transl)].
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本文引用的文献
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Milk-like fluid in a mammary adenocarcinoma: biochemical characterization.
Science. 1967 Feb 17;155(3764):826-7. doi: 10.1126/science.155.3764.826.
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Acquired hormonal dependence of milk protein synthesis in mammary carcinoma cells.乳腺癌细胞中乳蛋白合成的获得性激素依赖性
Endocrinology. 1969 May;84(5):1213-7. doi: 10.1210/endo-84-5-1213.
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Specific and nonspecific physicochemical interactions of glucocorticoids and related steroids with rat thymus cells in vitro.糖皮质激素及相关甾体与大鼠胸腺细胞在体外的特异性和非特异性物理化学相互作用
J Biol Chem. 1968 Nov 10;243(21):5556-65.
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Specific estrogen-binding capacity of the cytoplasmic receptor in normal and neoplastic breast tissues of humans.人类正常和肿瘤性乳腺组织中细胞质受体的特异性雌激素结合能力。
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Will the best model of breast cancer please come forward?乳腺癌的最佳模型，请站出来好吗？
Natl Cancer Inst Monogr. 1971 Dec;34:43-54.
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