激素对乳腺癌中乳糖合成酶的刺激作用。
Hormonal stimulation of lactose synthetase in mammary carcinoma.
作者信息
McGuire W L
出版信息
Science. 1969 Sep 5;165(3897):1013-4. doi: 10.1126/science.165.3897.1013.
PMID:4896309
Abstract
A transplantable rat mammary carcinoma (R3230AC) synthesizes significant quantities of the mammary gland enzyme lactose synthetase in the immature virgin female rat. In this hormonal environment, mammary glands do not synthesize the enzyme. Prolactin further stimulates the enzyme activity in the tumors to levels found only in mammary glands of rats in late pregnancy or during lactation.
摘要
一种可移植的大鼠乳腺癌（R3230AC）在未成熟的处女雌性大鼠体内能合成大量乳腺酶乳糖合成酶。在这种激素环境下，乳腺并不合成该酶。催乳素进一步刺激肿瘤中的酶活性，使其达到仅在妊娠后期或哺乳期大鼠乳腺中才有的水平。
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