肉毒杆菌毒素对交感神经至输精管传递的作用。
Action of botulinum toxin on transmission from sympathetic nerves to the vas deferens.
作者信息
Holman M E, Spitzer N C
出版信息
Br J Pharmacol. 1973 Feb;47(2):431-3. doi: 10.1111/j.1476-5381.1973.tb08343.x.
Abstract
Botulinum toxin (Type A) depressed or abolished transmission from postganglionic nerves to smooth muscle of isolated preparations of guinea-pig and mouse vas deferens. The time course of blockade was 2 to 6 times slower than that observed with the same concentration of the same batch of toxin on the rat diaphragm. Spontaneous excitatory junction potentials were still observed after 7 h exposure, indicating that the smooth muscle membrane was still able to respond to noradrenaline. Depression of transmission is probably due to a presynaptic action of unknown nature.
摘要
A型肉毒杆菌毒素使豚鼠和小鼠离体输精管标本中节后神经至平滑肌的传递受到抑制或消除。阻断的时间进程比用同一批次相同浓度的毒素作用于大鼠膈肌时观察到的慢2至6倍。暴露7小时后仍可观察到自发兴奋性接头电位，这表明平滑肌膜仍能对去甲肾上腺素作出反应。传递的抑制可能是由于性质不明的突触前作用。
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