Rimsten A, Adami H O, Wahren B, Nordin B
Br J Cancer. 1979 Feb;39(2):109-15. doi: 10.1038/bjc.1979.20.
A series of consecutive unselected patients with primary breast carcinoma and their age-matched controls were studied for serum CEA in relation to clinical findings. Raised CEA was found in a similar frequency in patients with primary breast cancer (pre- and postoperative) and in the control women: 16%, 11% and 11%, respectively, exceeded the selected upper limit of the reference range (13 ng/ml) with a double-antibody radioimmunoassay. In the breast-cancer patients, however, 48% of the raised CEA levels exceeded 16 ng/ml, compared with only 20% in the controls. Significant correlations (r approximately 0.3) were found between CEA levels and tumour size, TNM classification and a combined clinical and histopathological classification. A high frequency of raised CEA values in the advanced breast-cancer patients was the essential contribution to these positive correlations. A correlation coefficient of 0.6 was found between pre- and postoperative CEA values. The frequency of smoking and/or chronic disease was unexpectedly high in patients as well as in controls with high CEA.
对一系列连续入选的原发性乳腺癌患者及其年龄匹配的对照者进行了血清癌胚抗原（CEA）与临床检查结果相关性的研究。原发性乳腺癌患者（术前和术后）与对照女性中CEA升高的频率相似：采用双抗体放射免疫测定法时，分别有16%、11%和11%的患者超过选定的参考范围上限（13 ng/ml）。然而，在乳腺癌患者中，48%的CEA升高水平超过16 ng/ml，而对照组中仅为20%。CEA水平与肿瘤大小、TNM分类以及临床和组织病理学综合分类之间存在显著相关性（r约为0.3）。晚期乳腺癌患者中CEA值升高的高频率是这些正相关的主要原因。术前和术后CEA值之间的相关系数为0.6。在CEA升高的患者和对照者中，吸烟和/或慢性病的发生率出乎意料地高。
