Pierard G E, Ackerman A B
Br J Dermatol. 1979 Mar;100(3):251-6. doi: 10.1111/j.1365-2133.1979.tb06196.x.
The histopathological alterations induced by PUVA within the skin are reported in a patient treated for psoriasis. The main impact is located at the site of former psoriatic plaques in which the target is the microvasculature. A residual coating sheath is present around vessels and fibrosis appears in the superficial dermis. These remodellings interfere with the normal dermo--epidermal relationships; the epidermis contains atypical keratinocytes, and melanocytes are no longer recognizable.
据报道，一名接受光化学疗法（PUVA）治疗的银屑病患者皮肤出现了组织病理学改变。主要影响位于先前银屑病斑块所在部位，其靶点是微脉管系统。血管周围存在残留的包被鞘，浅真皮层出现纤维化。这些重塑干扰了正常的真皮与表皮关系；表皮含有非典型角质形成细胞，黑素细胞不再可辨认。
