Piérard G E, Nikkels A, Arrese Estrada J, Ben Mosbah T, Piérard-Franchimont C
Department of Dermatopathology, University of Liège, Belgium.
Virchows Arch A Pathol Anat Histopathol. 1991;418(4):311-4. doi: 10.1007/BF01600159.
We studied the fate of dermal dendrocytes in patients treated with psoralens and ultraviolet light by combining immunohistochemistry and computerized image analysis. Factor-XIIIa-positive dermal dendrocytes were found to be altered in these patients. When compared with controls, dermal dendrocytes were often increased in number and had an uneven size and tissue distribution. Their cytoplasm was occasionally fragmented. These changes were more pronounced when early photosclerosis was present. The alterations described probably reflect vascular changes, and may be responsible for immunomodulating actions and disorder of the connective tissue structure induced by ultraviolet light.
我们通过结合免疫组织化学和计算机图像分析，研究了补骨脂素和紫外线治疗患者真皮树突状细胞的命运。发现这些患者中因子 XIIIa 阳性的真皮树突状细胞发生了改变。与对照组相比，真皮树突状细胞数量常增加，大小和组织分布不均。其细胞质偶尔会出现碎片化。早期光硬化存在时，这些变化更为明显。所述改变可能反映了血管变化，并且可能是紫外线诱导的免疫调节作用和结缔组织结构紊乱的原因。
