Neumann H, Klein E, Russell R M, Epstein S
Br J Haematol. 1979 Apr;41(4):519-32. doi: 10.1111/j.1365-2141.1979.tb05890.x.
A characteristic alkaline phosphatase (orthophosphoric monoester hydrolase, alkaline pH optimum, EC 3.1.3.1) was detected in the sera of most patients with infectious mononucleosis, acute and chronic lymphatic leukaemia, non-Hodgkin's lymphoma, Burkitt's lymphoma and nasopharyngeal carcinoma. The enzyme was also present in the sera of nine out of 26 patients with cancer of the cervix. N-APase in these cases counted 30-100% of the total alkaline phosphatase activity. N-APase was absent from the sera of healthy individuals and of patients with acute and chronic granulocytic leukaemia, breast cancer, colon cancer, rheumatoid arthritis, ulcerative colitis, systemic lupus erythematosis, hepatitis and obstructive jaundice. Only three of 22 patients with Hodgkin's disease showed n-apase activity in the serum. In infectious mononucleosis the presence of N-APase activity was well correlated with the clinical course. In 13 cases studied, the clinical improvement was associated with the decrease or disappearance of N-APase activity. N-APase activity could not be detected in white cells of acute myeloid leukaemic patients, nor in the cells of myeloid blastic crisis of chronic granulocytic leukaemia. It was present in the cells of lymphoid blastic crisis of chronic granulocytic leukaemia.
在大多数传染性单核细胞增多症、急慢性淋巴细胞白血病、非霍奇金淋巴瘤、伯基特淋巴瘤和鼻咽癌患者的血清中检测到一种特征性碱性磷酸酶（正磷酸单酯水解酶，最适pH为碱性，EC 3.1.3.1）。在26例宫颈癌患者中，有9例患者的血清中也存在这种酶。在这些病例中，N-碱性磷酸酶占总碱性磷酸酶活性的30%-100%。健康个体以及急慢性粒细胞白血病、乳腺癌、结肠癌、类风湿性关节炎、溃疡性结肠炎、系统性红斑狼疮、肝炎和阻塞性黄疸患者的血清中不存在N-碱性磷酸酶。在22例霍奇金病患者中，只有3例血清显示有N-碱性磷酸酶活性。在传染性单核细胞增多症中，N-碱性磷酸酶活性的存在与临床病程密切相关。在所研究的13例病例中，临床症状的改善与N-碱性磷酸酶活性的降低或消失有关。在急性髓细胞白血病患者的白细胞中以及慢性粒细胞白血病髓细胞急变期的细胞中均未检测到N-碱性磷酸酶活性。它存在于慢性粒细胞白血病淋巴细胞急变期的细胞中。
