Neumann H, Moran E M, Russell R M, Rosenberg I H
Science. 1974 Oct 11;186(4159):151-3. doi: 10.1126/science.186.4159.151.
A distinct alkaline phosphatase (phosphatase N) was demonstrated in the serum of patients with acute lymphatic leukemia, chronic lymphatic leukemia, and infectious mononucleosis. This enzyme closely resembles that extracted from the thymus of mice with lymphoma or lymphatic leukemia, both in its electro-phoretic mobility and its substrate specificity. The phosphatase N activity was related to the clinical state of patients with lymphatic leukemia and disappeared with recovery from infectious mnononucleosis.
在急性淋巴细胞白血病、慢性淋巴细胞白血病和传染性单核细胞增多症患者的血清中发现了一种独特的碱性磷酸酶（磷酸酶N）。这种酶在电泳迁移率和底物特异性方面都与从患有淋巴瘤或淋巴细胞白血病的小鼠胸腺中提取的酶极为相似。磷酸酶N的活性与淋巴细胞白血病患者的临床状态相关，并且在传染性单核细胞增多症康复后消失。
