兔滑膜细胞和软骨细胞的干扰素反应性。
Interferon responsiveness of rabbit synovial cells and chondrocytes.
作者信息
Craig C P, Gordon S L, Greer R B
出版信息
Infect Immun. 1973 Sep;8(3):425-9. doi: 10.1128/iai.8.3.425-429.1973.
Abstract
Rabbit synovial cells (SC), articular chondrocytes (AC), and epiphyseal (EC) chondrocytes were grown in vitro. A portion of the spectrum of human pathogenic viruses infective for the cells was determined. Responses of the cells to different viruses or a chemical inducer of interferon varied, with EC responding vigorously and with high titers, AC responding only to chemical inducer and influenza virus, and SC producing no detectable interferon. All cells supported prolonged growth of influenza virus without showing microscopic cytopathology.
摘要
兔滑膜细胞（SC）、关节软骨细胞（AC）和骨骺软骨细胞（EC）在体外培养。测定了可感染这些细胞的一部分人类致病病毒谱。细胞对不同病毒或干扰素化学诱导剂的反应各不相同，其中EC反应强烈且滴度高，AC仅对化学诱导剂和流感病毒有反应，而SC未产生可检测到的干扰素。所有细胞均支持流感病毒的长期生长，且未出现微观细胞病变。
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