磷酸二酯酶合成的调控：对环磷酸腺苷依赖性蛋白激酶的需求。
Regulation of phosphodiesterase synthesis: requirement for cyclic adenosine monophosphate-dependent protein kinase.
作者信息
Bourne H R, Tomkins G M, Dion S
出版信息
Science. 1973 Sep 7;181(4103):952-4. doi: 10.1126/science.181.4103.952.
PMID:4354229
Abstract
Endogenous cyclic adenosine monophosphate (AMP) and its dibutyryl derivative increase cyclic AMP phosphodiesterase activity in cultured lymphoma cells. This effect is prevented by cycloheximide. A variant population of cells deficient in cyclic AMP-dependent protein kinase contains lower basal phosphodiesterase activity, which cannot be induced by cyclic AMP.
摘要
内源性环磷酸腺苷（AMP）及其二丁酰衍生物可增加培养的淋巴瘤细胞中环磷酸腺苷磷酸二酯酶的活性。这种作用可被放线菌酮阻止。缺乏环磷酸腺苷依赖性蛋白激酶的细胞变异群体具有较低的基础磷酸二酯酶活性，且不能被环磷酸腺苷诱导。
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