Gardner M B, Henderson B E, Officer J E, Rongey R W, Parker J C, Oliver C, Estes J D, Huebner R J
J Natl Cancer Inst. 1973 Oct;51(4):1243-54. doi: 10.1093/jnci/51.4.1243.
A high incidence of spontaneous lower-limb paralysis occurred in a population of wild mice () which had a high incidence of naturally occurring lymphoma and elevated indigenous type-C virus activity. Experimental transmission evidence indicated that both the neurologic and lymphomatous disorders almost certainly were caused by the indigenous type-C virus. The virus appeared to have a direct neurotropic effect on anterior horn neurons in the lower spinal cord.
在一群野生小鼠中,自发性下肢麻痹的发生率很高,这群小鼠自然发生淋巴瘤的发生率很高,且内源性C型病毒活性升高。实验性传播证据表明,神经疾病和淋巴瘤几乎肯定是由内源性C型病毒引起的。该病毒似乎对脊髓下部的前角神经元有直接的嗜神经作用。