脊髓灰质炎病毒粒子、天然存在的空衣壳和14S前体颗粒的多肽组成。
Polypeptide composition of poliovirions, naturally occurring empty capsids, and 14S precursor particles.
作者信息
Phillips B A, Fennell R
出版信息
J Virol. 1973 Aug;12(2):291-9. doi: 10.1128/JVI.12.2.291-299.1973.
Abstract
The three serotypes of poliovirus were compared with respect to their polypeptide composition. Type 1, 2, and 3 strains were clearly different from each other in the electrophoretic mobilities of their larger structural polypeptides. Some of the viral polypeptides formerly identified as single peaks (e.g., VP 2) were shown to contain multiple components, indicating that purified virions contain at least six polypeptides. Three type 1 strains were indistinguishable in their viral polypeptides. A quantitative estimate was made of the polypeptide composition of the type 1 Mahoney poliovirion, as well as of naturally occurring empty capsids and 14S precursor particles. The data are discussed in light of the antigenic differences among polioviruses and the possible modes of virion morphogenesis.
摘要
对脊髓灰质炎病毒的三种血清型进行了多肽组成方面的比较。1型、2型和3型毒株在其较大结构多肽的电泳迁移率上明显彼此不同。一些先前被鉴定为单峰的病毒多肽（例如VP2）显示含有多种成分，这表明纯化的病毒粒子至少含有六种多肽。三株1型毒株在病毒多肽方面无法区分。对1型马奥尼脊髓灰质炎病毒粒子以及天然存在的空衣壳和14S前体颗粒的多肽组成进行了定量估计。根据脊髓灰质炎病毒之间的抗原差异以及病毒粒子形态发生的可能模式对数据进行了讨论。
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