Hahn P, Koldovský O
Biol Neonate. 1979;35(3-4):194-7. doi: 10.1159/000241172.
Male rats were weaned normally (NW; day 30 after birth) or prematurely (PW; day 18) to a Purina Chow diet. Serum cholesterol levels and the activities of some enzymes of fatty acid and glucose metabolism were determined when the animals were 6 and 10 months old and, in the older group, also after 2 days of starvation. Blood cholesterol levels rose with age and at 10 months were higher in PW than NW rats. This difference disappeared after starvation. Hepatic pyruvate kinase (PK) activity was the same in fed NW and PW animals but was significantly higher in starved PW than NW rats. Hepatic phosphoenolpyruvate carboxykinase (PEPcK) activity was lower in NW than in PW rats, but this difference disappeared on starvation. In white fat, starvation caused a fall in PEPcK activity in both groups. In general, the effect of starvation did not accentuate the differences between the two groups. However, PEPcK activity in white fat increased with age about fourfold.
雄性大鼠正常断奶（NW；出生后第30天）或提前断奶（PW；出生后第18天），并给予普瑞纳饲料。在动物6个月和10个月大时，以及在老年组中，饥饿2天后，测定血清胆固醇水平以及一些脂肪酸和葡萄糖代谢酶的活性。血液胆固醇水平随年龄增长而升高，10个月时，PW大鼠的胆固醇水平高于NW大鼠。饥饿后这种差异消失。喂食的NW和PW动物肝脏丙酮酸激酶（PK）活性相同，但饥饿后PW大鼠的肝脏PK活性显著高于NW大鼠。NW大鼠肝脏磷酸烯醇式丙酮酸羧激酶（PEPcK）活性低于PW大鼠，但饥饿后这种差异消失。在白色脂肪中，饥饿导致两组的PEPcK活性下降。总体而言，饥饿的影响并未加剧两组之间的差异。然而，白色脂肪中的PEPcK活性随年龄增长增加了约四倍。
