Nazarov G F, Petrishchev N N, Stanekvich A N
Biull Eksp Biol Med. 1979 Apr;87(4):304-5.
The skin inflammation was induced by xylol application in experiments on rats. Exogenous and endogenous hyperheparinemia was found not to influence the dynamics of microcirculatory changes in the inflammatory area at the onset of its development, vascular permeability being significantly decreased. It is suggested that decreased vascular permeability plays an important role in the mechanism of antiexudative heparin action.
在大鼠实验中，通过涂抹二甲苯诱发皮肤炎症。研究发现，外源性和内源性高肝素血症在炎症区域发展初期并不影响微循环变化的动态过程，血管通透性显著降低。提示血管通透性降低在肝素抗渗出作用机制中起重要作用。
