Kennedy A
J Clin Pathol. 1973 Oct;26(10):792-9. doi: 10.1136/jcp.26.10.792.
;Sclerosing haemangioma' is a name which has been applied to a group of uncommon benign pulmonary lesions characterized by their papillary nature, a sclerotic stroma containing lipid, and, in some cases, evidence of haemorrhage. There is little evidence that these lesions are really angiomatous. Studies of two examples removed surgically after being discovered as incidental radiographic findings, show that the cells lining the papillae have large vacuoles which contain whorled, electron-dense inclusions. These epithelial cells have the features of granular pneumonocytes, cells known to contain phospholipid. Both lipid and cholesterol are abundant in the stroma of both tumours and the lipid is distributed in a nodular fashion. Histochemically the lipid gives a strong reaction to stains for phospholipid and it is suggested that the lipid is derived, not from the haemorrhage, but is produced by the epithelial element of the tumour.
“硬化性血管瘤”是一个用于描述一组罕见的良性肺病变的名称，其特征为乳头状结构、含有脂质的硬化性间质，以及在某些情况下存在出血迹象。几乎没有证据表明这些病变实际上是血管瘤。对两例经手术切除的病例进行研究，这两例最初是在偶然的影像学检查中被发现的，研究显示乳头内衬细胞有大空泡，其中含有呈涡状、电子致密的包涵体。这些上皮细胞具有颗粒性肺细胞的特征，已知这种细胞含有磷脂。两种肿瘤的间质中脂质和胆固醇都很丰富，且脂质呈结节状分布。组织化学分析表明，脂质对磷脂染色有强烈反应，提示脂质并非来源于出血，而是由肿瘤的上皮成分产生。
