Bellet E M, Casida J E
Science. 1973 Dec 14;182(4117):1135-6. doi: 10.1126/science.182.4117.1135.
4-Isopropyl-2,6,7-trioxa-1-phosphabicyclo[2.2.2]octane 1-oxide has a mouse intraperitoneal lethal dose, 50 percent effective, of 0.18 milligram per kilogram of body weight. Related compounds used by many chemical researchers are also highly toxic. Brain acetylcholinesterase inhibition is not involved in their mode of action. The structural similarity of these compounds to adenosine 3',5'-monophosphate (cyclic AMP) is of interest.
4-异丙基-2,6,7-三氧杂-1-磷杂双环[2.2.2]辛烷1-氧化物的小鼠腹腔半数致死剂量为每千克体重0.18毫克。许多化学研究人员使用的相关化合物也具有高毒性。它们的作用方式不涉及脑乙酰胆碱酯酶抑制。这些化合物与腺苷3',5'-单磷酸（环磷酸腺苷）的结构相似性令人关注。
