5-羟色胺在药物诱导的抗伤害感受中的作用
On the role of 5-hydroxytryptamine in drug-induced antinociception.
作者信息
Sugrue M F
出版信息
Br J Pharmacol. 1979 Apr;65(4):677-81. doi: 10.1111/j.1476-5381.1979.tb07881.x.
Abstract
- The effects of four specific inhibitors of 5-hydroxytryptamine (K-HT) uptake on morphine-, methadone- or pethidine-induced antinociception was studied in rats. Antinociception was assessed by means of hot plate (55 degrees C) reaction times. The effect of the compounds on the uptake of [3H]-5-HT into rat whole brain synaptosomes was also investigated. 2. Pretreatment with Org 6582, citalopram, zimelidine or femoxetine at doses devoid of antinociceptive activity potentiated morphine- but not methadone- or pethidine-induced antinociception. 3. A temporal correlation existed between the ability of Org 6582 to potentiate morphine-induced antinociception and to block synaptosomal [3H]-5-HT uptake. 4. 5-HT plays a critical role in the antinociceptive effect of morphine but not of methadone or pethidine.
摘要
- 研究了5-羟色胺（K-HT）摄取的四种特异性抑制剂对大鼠吗啡、美沙酮或哌替啶诱导的抗伤害感受的影响。通过热板（55摄氏度）反应时间评估抗伤害感受。还研究了这些化合物对[3H]-5-羟色胺摄取到大鼠全脑突触体中的影响。2. 用无抗伤害感受活性剂量的Org 6582、西酞普兰、齐美利定或氟西汀预处理可增强吗啡诱导的抗伤害感受，但不能增强美沙酮或哌替啶诱导的抗伤害感受。3. Org 6582增强吗啡诱导的抗伤害感受和阻断突触体[3H]-5-羟色胺摄取的能力之间存在时间相关性。4. 5-羟色胺在吗啡的抗伤害感受作用中起关键作用，但在美沙酮或哌替啶的抗伤害感受作用中不起关键作用。
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引用本文的文献
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2
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本文引用的文献
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Effect of midbrain raphe lesion on the antinociceptive action of morphine and other analgesics in rats.中脑缝际核损伤对大鼠吗啡及其他镇痛药抗伤害感受作用的影响。
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