5-羟色胺参与度冷丁和吗啡对小鼠的镇痛作用。
Involvement of 5-hydroxytryptamine in the analgesic action of pethidine and morphine in mice.
作者信息
Botting R, Morinan A
出版信息
Br J Pharmacol. 1982 Apr;75(4):579-85. doi: 10.1111/j.1476-5381.1982.tb09177.x.
Abstract
1 Groups of mice were pretreated with the 5-hydroxytryptamine (5-HT) depletors, fenfluramine or p-chlorophenylalanine (PCPA), followed by pethidine or morphine. 2 Fenfluramine alone produced a short lasting analgesia but PCPA was without any effect. 3 Pethidine and morphine both increased hot plate reaction times measured after 30 min. 4 Pretreatment with PCPA attenuated morphine analgesia but did not affect pethidine analgesia. Fenfluramine did not alter the response to either analgesic. 5 PCPA produced a significant depletion of brain 5-HT levels which was not reversed by the analgesics. The fenfluramine-induced decrease in 5-HT was reversed by morphine but not by pethidine. 6 The results support the involvement of 5-HT in the antinociceptive action of morphine in the mouse.
摘要
- 将小鼠分组，先用5-羟色胺（5-HT）耗竭剂、芬氟拉明或对氯苯丙氨酸（PCPA）进行预处理，然后给予哌替啶或吗啡。2. 单独使用芬氟拉明产生短暂的镇痛作用，但PCPA没有任何效果。3. 哌替啶和吗啡均增加了30分钟后测得的热板反应时间。4. 用PCPA预处理可减弱吗啡的镇痛作用，但不影响哌替啶的镇痛作用。芬氟拉明不改变对任何一种镇痛药的反应。5. PCPA使脑5-HT水平显著降低，且这种降低未被镇痛药逆转。芬氟拉明引起的5-HT减少被吗啡逆转，但未被哌替啶逆转。6. 结果支持5-HT参与小鼠吗啡的抗伤害感受作用。
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