无细胞体系中的磺胺类构效关系。2. 含磺胺类叶酸类似物形成的证据。 - Suppr

Suppr

超能文献

Sulfonamide structure-activity relationships in a cell-free system. 2. Proof for the formation of a sulfonamide-containing folate analog.

作者信息

Bock L, Miller G H, Schaper K J, Seydel J K

出版信息

J Med Chem. 1974 Jan;17(1):23-8. doi: 10.1021/jm00247a006.

DOI:10.1021/jm00247a006

PMID:4357096

Abstract

摘要

相似文献

Sulfonamide structure-activity relationships in a cell-free system. 2. Proof for the formation of a sulfonamide-containing folate analog.无细胞体系中的磺胺类构效关系。2. 含磺胺类叶酸类似物形成的证据。

J Med Chem. 1974 Jan;17(1):23-8. doi: 10.1021/jm00247a006.

The biosynthesis of pteridines.蝶啶的生物合成。

Adv Enzymol Relat Areas Mol Biol. 1971;35:35-77. doi: 10.1002/9780470122808.ch2.

Sulfonamide structure-activity relationship in a cell-free system. Correlation of inhibition of folate synthesis with antibacterial activity and physicochemical parameters.无细胞体系中磺胺类药物的构效关系。叶酸合成抑制与抗菌活性及理化参数的相关性。

J Med Chem. 1972 Jul;15(7):700-6. doi: 10.1021/jm00277a002.

The enzymic synthesis of dihydropteroate and dihydrofolate by Plasmodium berghei.伯氏疟原虫对二氢蝶酸和二氢叶酸的酶促合成。

J Protozool. 1973 Aug;20(3):459-64. doi: 10.1111/j.1550-7408.1973.tb00926.x.

Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase.抗菌磺胺类药物靶点二氢蝶酸合酶的晶体结构

Nat Struct Biol. 1997 Jun;4(6):490-7. doi: 10.1038/nsb0697-490.

The biosynthesis of folic acid. IX. Purification and properties of the enzymes required for the formation of dihydropteroic acid.叶酸的生物合成。IX. 二氢蝶酸形成所需酶的纯化及性质

J Biol Chem. 1969 Mar 25;244(6):1582-92.

The enzymatic synthesis of dihydrofolate and dihydropteroate in cell-free preparations from wild-type and sulfonamide-resistant pneumococcus.野生型和磺胺耐药性肺炎球菌无细胞制剂中二氢叶酸和二氢蝶酸的酶促合成。

Biochemistry. 1966 Jan;5(1):67-74. doi: 10.1021/bi00865a010.

Inhibition of folate biosynthesis and function as a basis for chemotherapy.抑制叶酸生物合成及以此作为化疗的基础。

Adv Enzymol Relat Areas Mol Biol. 1965;27:417-68. doi: 10.1002/9780470122723.ch9.

Mechanism of action of the folate blocker diaminodiphenylsulfone (dapsone, DDS) studied in E. coli cell-free enzyme extracts in comparison to sulfonamides (SA).与磺胺类药物（SA）相比，在大肠杆菌无细胞酶提取物中研究叶酸阻断剂二氨基二苯砜（氨苯砜，DDS）的作用机制。

Int J Lepr Other Mycobact Dis. 1980 Mar;48(1):18-29.

P-Aminobenzoic acid derivatives. Mode of action and structure-activity relationships in a cell-free system (Escherichia coli).对氨基苯甲酸衍生物。无细胞系统（大肠杆菌）中的作用模式及构效关系

J Med Chem. 1977 Mar;20(3):439-47. doi: 10.1021/jm00213a023.

引用本文的文献

The aminosalicylate - folate connection.氨基水杨酸盐-叶酸的关联。

Drug Metab Rev. 2024 Feb;56(1):80-96. doi: 10.1080/03602532.2024.2303507. Epub 2024 Jan 17.

Mutual potentiation drives synergy between trimethoprim and sulfamethoxazole.甲氧苄啶与磺胺甲噁唑的协同作用是相互促进的。

Nat Commun. 2018 Mar 8;9(1):1003. doi: 10.1038/s41467-018-03447-x.

Subversion of Metabolic Wasting as the Mechanism for -Linked Sulfamethoxazole Resistance.代谢性消耗的颠覆作为与磺胺甲恶唑耐药性相关的机制

mBio. 2017 Nov 28;8(6):e01769-17. doi: 10.1128/mBio.01769-17.

Pterin-sulfa conjugates as dihydropteroate synthase inhibitors and antibacterial agents.蝶呤-磺胺缀合物作为二氢蝶酸合酶抑制剂和抗菌剂。

Bioorg Med Chem Lett. 2016 Aug 15;26(16):3950-4. doi: 10.1016/j.bmcl.2016.07.006. Epub 2016 Jul 4.

Crystal structure of 4-[(5-methyl-isoxazol-3-yl)amino-sulfon-yl]anilinium 3,5-di-nitro-salicylate.4-[(5-甲基-异恶唑-3-基)氨基-磺酰基]苯胺 3,5-二硝基水杨酸盐的晶体结构

Acta Crystallogr E Crystallogr Commun. 2015 May 13;71(Pt 6):618-20. doi: 10.1107/S2056989015008701. eCollection 2015 Jun 1.

Opposing effects of target overexpression reveal drug mechanisms.靶点过表达的相反作用揭示药物机制。

Nat Commun. 2014 Jul 1;5:4296. doi: 10.1038/ncomms5296.

The evolutionary rate of antibacterial drug targets.抗菌药物靶点的进化速度。

BMC Bioinformatics. 2013 Feb 1;14:36. doi: 10.1186/1471-2105-14-36.

Increased abundance and transferability of resistance genes after field application of manure from sulfadiazine-treated pigs.磺胺嘧啶处理过的猪粪田间施用后，抗性基因的丰度和可转移性增加。

Appl Environ Microbiol. 2013 Mar;79(5):1704-11. doi: 10.1128/AEM.03172-12. Epub 2013 Jan 11.

Catalysis and sulfa drug resistance in dihydropteroate synthase.二氢叶酸合成酶中的催化作用和磺胺类药物耐药性。

Science. 2012 Mar 2;335(6072):1110-4. doi: 10.1126/science.1214641.

The dihydropteroate synthase gene, folP, is near the leucine tRNA gene, leuU, on the Escherichia coli chromosome.二氢蝶酸合酶基因folP在大肠杆菌染色体上靠近亮氨酸tRNA基因leuU的位置。

J Bacteriol. 1993 Dec;175(23):7743-4. doi: 10.1128/jb.175.23.7743-7744.1993.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验