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皮质锥体束中间神经元及其对L-谷氨酸的敏感性。

Cortical pyramidal tract interneurones and their sensitivity to L-glutamic acid.

作者信息

Stone T W

出版信息

J Physiol. 1973 Aug;233(1):211-25. doi: 10.1113/jphysiol.1973.sp010306.

DOI:10.1113/jphysiol.1973.sp010306
PMID:4357199
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1350548/
Abstract
  1. Pyramidal tract interneurones, defined as neurones which are activated synaptically as a result of pyramidal tract stimulation, have been identified in the rat cerebral cortex. The number of evoked spikes depended upon stimulus strength, and stimulation in a specific thalamic nucleus produced a burst of activity lasting for up to 1 sec.2. These cells are readily excited by a brief (50 msec) pulse of glutamate applied by micro-iontophoresis. Other, unidentified cells are not so responsive.3. Synaptically evoked spikes resulting from pyramidal tract stimulation can be blocked by the iontophoretic and I.P. administration of substances shown to antagonize glutamate excitation of cells.4. The results support suggestions that glutamic acid is a neurotransmitter in the cerebral cortex. The evidence presented further indicates that glutamic acid could be the transmitter released by the pyramidal tract.
摘要

  1. 锥体束中间神经元，即因锥体束刺激而通过突触激活的神经元，已在大鼠大脑皮层中被识别出来。诱发的尖峰数量取决于刺激强度，在特定丘脑核团进行刺激会产生持续长达1秒的一阵活动。

  2. 通过微量离子电泳施加的短暂（50毫秒）谷氨酸脉冲很容易使这些细胞兴奋。其他未识别的细胞则没有如此反应。

  3. 由锥体束刺激产生的突触诱发尖峰可被离子电泳和腹腔注射显示能拮抗细胞谷氨酸兴奋作用的物质所阻断。

  4. 这些结果支持谷氨酸是大脑皮层神经递质的观点。所提供的证据进一步表明谷氨酸可能是锥体束释放的递质。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9da5/1350548/e45977a1a975/jphysiol00953-0221-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9da5/1350548/e45977a1a975/jphysiol00953-0221-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9da5/1350548/e45977a1a975/jphysiol00953-0221-a.jpg

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