谷氨酸是锥体束神经递质吗？
Is glutamic acid the pyramidal tract neurotransmitter?
作者信息
Stone T W
出版信息
Experientia. 1976 May 15;32(5):581-3. doi: 10.1007/BF01990174.
PMID:6297
Abstract
Applied by microiontophoresis, 1-hydroxy-3-amino-pyrrolidone-2 (HA-966) antagonized excitation by glutamic acid but not by acetylcholine of neurones in the rat cuneate nucleus. HA-966 blocked the short latency excitation of cuneate neurones following stimulation of the pyramidal tract on 28 of 40 cells (70%). Thus, glutamate or a related amino-acid may be the neurotransmitter released by pyramidal tract neurones.
摘要
通过微离子电泳施加的1-羟基-3-氨基-吡咯烷酮-2（HA-966）可拮抗大鼠楔状核中谷氨酸引起的神经元兴奋，但不能拮抗乙酰胆碱引起的兴奋。HA-966阻断了40个细胞中28个（70%）在刺激锥体束后楔状神经元的短潜伏期兴奋。因此，谷氨酸或一种相关氨基酸可能是锥体束神经元释放的神经递质。
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