巨噬细胞与淋巴细胞在体外对靶细胞破坏中的协同作用。
Macrophage and lymphocyte co-operation in target cell destruction in vitro.
作者信息
Zembala M, Ptak W, Hanczakowska M
出版信息
Clin Exp Immunol. 1973 Nov;15(3):461-6.
Abstract
It has been shown that CBA mouse lymphocytes cultured in the presence of allogeneic fibroblasts or syngeneic polyoma virus-induced tumour cells became specifically immunized. These immunized lymphocytes, however, are by themselves non-cytotoxic and only cause target cell killing when mixed with normal macrophages. The reaction is immunologically specific and seems to depend on the antigenic differences between lymphocytes and target cells. The mechanism of the interaction between the immunized lymphocytes and the normal macrophages in the cytotoxic killing of target cells is discussed.
摘要
已经表明，在同种异体成纤维细胞或同基因多瘤病毒诱导的肿瘤细胞存在的情况下培养的CBA小鼠淋巴细胞会发生特异性免疫。然而，这些免疫淋巴细胞本身没有细胞毒性，只有在与正常巨噬细胞混合时才会导致靶细胞杀伤。这种反应具有免疫特异性，似乎取决于淋巴细胞和靶细胞之间的抗原差异。本文讨论了免疫淋巴细胞与正常巨噬细胞在靶细胞细胞毒性杀伤中的相互作用机制。
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