Kveim M, Nesbakken R, Bredesen J E
Scand J Clin Lab Invest. 1979 Nov;39(7):645-52. doi: 10.1080/00365517909108869.
Acetate, pyruvate, lactate and NEFA concentrations, as well as acid-base-parameters were followed during bleeding, stable hypotension and re-infusion in five dogs. Mean arterial blood pressures were kept at 30 mmHg during the shock phase. An increase in acetate concentrations (P less than 0.01) was found in arterial as well as in venous plasma samples. The maximal mean acetate concentration was 0.19 mmol/l (during reinfusion) as compared to 0.06 mmol/l prior to bleeding. There was no difference between arterial and inferior caval venous concentrations. A definite correlation (r = 0.81, P less than 0.02) was found between blood pyruvate and plasma acetate concentrations. There was no correlation between plasma glucose or NEFA and acetate concentrations or between blood excess lactate and plasma acetate. The plasma acetate accumulation was negligible compared to the concomitant lactate accumulation (1:60), and did not contribute to the metabolic acidosis of shock. The correlation between acetate and pyruvate concentrations may indicate that pyruvate is the main substrate of acetate production in hypovolemic shock.
在五只犬的出血、稳定低血压和再灌注过程中，对乙酸盐、丙酮酸盐、乳酸盐和非酯化脂肪酸（NEFA）浓度以及酸碱参数进行了跟踪监测。在休克阶段，平均动脉血压维持在30 mmHg。动脉血和静脉血浆样本中均发现乙酸盐浓度升高（P<0.01）。乙酸盐的最大平均浓度为0.19 mmol/l（再灌注期间），而出血前为0.06 mmol/l。动脉血和下腔静脉血浓度之间无差异。发现血液丙酮酸盐和血浆乙酸盐浓度之间存在显著相关性（r = 0.81，P<0.02）。血浆葡萄糖或NEFA与乙酸盐浓度之间以及血液过量乳酸盐与血浆乙酸盐之间均无相关性。与同时发生的乳酸盐积累（1:60）相比，血浆乙酸盐积累可忽略不计，且对休克的代谢性酸中毒无影响。乙酸盐和丙酮酸盐浓度之间的相关性可能表明丙酮酸盐是低血容量性休克中乙酸盐产生的主要底物。
