RD-114病毒和猫RNA肿瘤病毒基因组RNA的结构特征及核苷酸序列分析
Structural characteristics and nucleotide sequence analysis of genomic RNA from RD-114 virus and feline RNA tumor viruses.
作者信息
East J L, Knesek J E, Allen P T, Dmochowski L
出版信息
J Virol. 1973 Nov;12(5):1085-91. doi: 10.1128/JVI.12.5.1085-1091.1973.
Abstract
The results of molecular hybridization experiments have demonstrated that the RNA genome of RD-114 virus has extensive nucleotide sequence homology with the RNA genome of Crandell virus, an endogenous type C virus of cats, but only limited homology with the RNA genomes of feline sarcoma virus and feline leukemia virus. The genomic RNAs of RD-114 virus and Crandell virus also had identical sedimentation coefficients of 50S. A structural rearrangement of genomic RNA did not exist within released RD-114 virions, whereas a structural rearrangement of genomic RNA did occur within feline sarcoma virions and feline leukemia virions after release from virus-producing cells.
摘要
分子杂交实验结果表明，RD - 114病毒的RNA基因组与猫内源性C型病毒克兰德尔病毒的RNA基因组具有广泛的核苷酸序列同源性，但与猫肉瘤病毒和猫白血病病毒的RNA基因组只有有限的同源性。RD - 114病毒和克兰德尔病毒的基因组RNA沉降系数也相同，均为50S。释放的RD - 114病毒粒子内不存在基因组RNA的结构重排，而猫肉瘤病毒粒子和猫白血病病毒粒子从产毒细胞释放后，其基因组RNA会发生结构重排。
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Partial characterization of RD114 virus by DNA-RNA hybridization studies.通过DNA-RNA杂交研究对RD114病毒进行部分特性鉴定。
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8
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Nat New Biol. 1973 Jul 11;244(132):54-6. doi: 10.1038/newbio244054a0.
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