通过分子杂交确定RNA肿瘤病毒的天然宿主分类：应用于一种候选人类病毒RD-114
Determination of natural host taxonomy of RNA tumor viruses by molecular hybridization: application to RD-114, a candidate human virus.
作者信息
Ruprecht R M, Goodman N C, Spiegelman S
出版信息
Proc Natl Acad Sci U S A. 1973 May;70(5):1437-41. doi: 10.1073/pnas.70.5.1437.
Abstract
The lysogenic bacteriophages and the RNA tumor viruses have in common the ability to add their genetic information to the genome of their host cells. The biological similarity extends further; data summarized here indicate that they both possess homology to the DNA of their uninfected indigenous hosts. Sharing of common sequences with normal host DNA has been established with avian, murine, feline, and primate oncornaviruses. This finding provides a method for determining the taxonomic position of the natural host of any new RNA tumor virus isolated. Application of this approach to RD-114 revealed extensive hybridization to normal cat DNA and little, if any, hybridization to human DNA. We conclude that the data assign a feline origin rather than a human origin to RD-114.
摘要
溶源性噬菌体和RNA肿瘤病毒的共同之处在于，它们能够将自身的遗传信息添加到宿主细胞的基因组中。这种生物学上的相似性还进一步延伸；此处总结的数据表明，它们与未感染的原生宿主的DNA都具有同源性。禽、鼠、猫和灵长类动物的肿瘤病毒已被证实与正常宿主DNA存在共同序列。这一发现为确定任何新分离出的RNA肿瘤病毒的天然宿主的分类地位提供了一种方法。将这种方法应用于RD - 114时，发现它与正常猫的DNA有广泛的杂交，而与人类DNA的杂交很少（如果有的话）。我们得出结论，这些数据表明RD - 114起源于猫而非人类。
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Determination of natural host taxonomy of RNA tumor viruses by molecular hybridization: application to RD-114, a candidate human virus.通过分子杂交确定RNA肿瘤病毒的天然宿主分类：应用于一种候选人类病毒RD-114
Proc Natl Acad Sci U S A. 1973 May;70(5):1437-41. doi: 10.1073/pnas.70.5.1437.
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Widespread presence, in chickens, of DNA complementary to the RNA genome of avian leukosis viruses.鸡体内广泛存在与禽白血病病毒RNA基因组互补的DNA。
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