口服脊髓灰质炎减毒活疫苗（萨宾株）大规模接种后日本脊髓灰质炎病毒分离株的特征分析
Characterization of poliovirus isolates in Japan after the mass vaccination with live oral poliomyelitis vaccine (Sabin).
作者信息
Tagaya I, Nakao C, Hara M, Yamadera S
出版信息
Bull World Health Organ. 1973 May;48(5):547-54.
From 1962 to 1968, 127 poliovirus isolates (92 from clinical specimens and 35 from healthy subjects) were subjected to intratypic serodifferentiation by the modified Wecker and McBride techniques. The two techniques gave concordant results for 103 strains, 91 of which were classified as vaccine-like, 9 as nonvaccine-like, and 3 as intermediate; 20 were classified as vaccine-like by one technique and as intermediate by the other, and 4 as nonvaccine-like by one technique and as intermediate by the other. The origin of the nonvaccine-like strains is unknown, but it is unlikely that they had been circulating in the community long. An rct/40-marker test of the isolates revealed a higher positivity rate than that found in field trials of Sabin vaccine. The results indicate that wild poliovirus has been almost completely eradicated from Japan.
1962年至1968年期间，采用改良的韦克（Wecker）和麦克布赖德（McBride）技术，对127株脊髓灰质炎病毒分离株（92株来自临床标本，35株来自健康受试者）进行了型内血清鉴别。两种技术对103株病毒的检测结果一致，其中91株被归类为疫苗样毒株，9株为非疫苗样毒株，3株为中间型毒株；20株在一种技术下被归类为疫苗样毒株，在另一种技术下被归类为中间型毒株，4株在一种技术下被归类为非疫苗样毒株，在另一种技术下被归类为中间型毒株。非疫苗样毒株的来源不明，但它们在社区中不太可能长期传播。对这些分离株进行的rct/40标记检测显示，其阳性率高于脊髓灰质炎减毒活疫苗（Sabin疫苗）现场试验中的阳性率。结果表明，野生脊髓灰质炎病毒在日本已几乎完全根除。
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