1962年至1968年期间，日本在引入口服脊髓灰质炎减毒活疫苗进行大规模接种后的脊髓灰质炎情况。
Poliomyelitis in Japan during the period 1962-68 after the introduction of mass vaccination with Sabin vaccine.
作者信息
Takatsu T, Tagaya I, Hirayama M
出版信息
Bull World Health Organ. 1973;49(2):129-37.
After the mass vaccination of children of susceptible age groups in Japan in 1961, the incidence of poliomyelitis decreased markedly. From 1962 to 1968 a total of 659 paralytic cases were officially notified. Detailed investigations of 626 cases reported to the Poliomyelitis Surveillance Committee revealed that only 185 (29.6%) were cases of paralysis clinically typical of poliomyelitis. Tests on 120 of these 185 cases showed that 75 (62.5%) were positive for poliovirus: 45 of these positive cases were temporally associated with the administration of live poliovirus vaccine and 36 had some residual disability. Wild types of poliovirus were rarely isolated. Only 36 vaccine-related cases of poliomyelitis were observed among the total of more than 11 million newborn infants vaccinated with Sabin vaccine in the period 1962-68.
1961年日本对易感年龄组儿童进行大规模疫苗接种后，脊髓灰质炎发病率显著下降。1962年至1968年，官方共通报了659例麻痹病例。对向脊髓灰质炎监测委员会报告的626例病例进行的详细调查显示，只有185例（29.6%）是临床上典型的脊髓灰质炎麻痹病例。对这185例病例中的120例进行检测，结果显示75例（62.5%）脊髓灰质炎病毒呈阳性：其中45例阳性病例在时间上与口服脊髓灰质炎减毒活疫苗的接种有关，36例有一些残留残疾。很少分离出野生型脊髓灰质炎病毒。在1962 - 1968年期间接种萨宾疫苗的1100多万新生儿中，仅观察到36例与疫苗相关的脊髓灰质炎病例。
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