Craighead J E, Kanich R E, Kessler J B
Am J Pathol. 1974 Feb;74(2):287-300.
Mice infected with the M variant of the encephalomyocarditis (EMC) virus develop lesions of the islets of Langerhans associated with a diabetes mellitus-like disease. Ultrastructural alterations become evident in capillaries and beta cells at a time when large amounts of virus are present in the pancreatic tissue. Although some beta cells become necrotic, degranulation and contraction of intact cells is the prominent lesion. Changes in the capillaries appear early in the course of the infection and later are associated with interstitial fibrosis in and around the islets. During early convalescence, beta cells are degranulated and exhibit striking alterations of cytoplasmic organelles. These changes appear to be consequent to increased metabolic activity by the residual insular tissue. Interestingly enough, specific lesions of the alpha cells are not observed.
感染脑心肌炎（EMC）病毒M变体的小鼠会出现与糖尿病样疾病相关的胰岛病变。当胰腺组织中存在大量病毒时，毛细血管和β细胞的超微结构改变变得明显。虽然一些β细胞会发生坏死，但完整细胞的脱颗粒和收缩是主要病变。毛细血管的变化在感染过程早期出现，后期与胰岛内及周围的间质纤维化有关。在早期恢复期，β细胞脱颗粒并表现出细胞质细胞器的显著改变。这些变化似乎是残余胰岛组织代谢活动增加的结果。有趣的是，未观察到α细胞的特异性病变。
