Manuel M A, Kurtz I, Saiphoo C S, Nedzelski J M
Can J Surg. 1979 May;22(3):274-7.
Renal failure and ototoxicity developed in two patients following wound irrigation with neomycin. In both patients the renal failure was reversible, but the deafness was progressive despite withdrawal of the neomycin. In one patient the serum neomycin concentration was still markedly elevated (42 microgram/ml) 2 days after use of the drug was discontinued. The authors suggest that irrigation of large open wounds with neomycin is dangerous since toxic blood concentrations may ensue. The benefits conferred by neomycin irrigation should be weighed against the possible danger of permanently impaired hearing.
两名患者在用新霉素进行伤口冲洗后出现了肾衰竭和耳毒性。两名患者的肾衰竭均为可逆性，但尽管停用了新霉素，耳聋仍在进展。一名患者在停用该药2天后血清新霉素浓度仍显著升高（42微克/毫升）。作者认为，用新霉素冲洗大面积开放性伤口是危险的，因为可能会出现有毒的血药浓度。新霉素冲洗带来的益处应与永久性听力受损的潜在风险相权衡。
