Johnson C A
School of Pharmacy, University of Wisconsin-Madison.
J Burn Care Rehabil. 1988 Mar-Apr;9(2):162-4. doi: 10.1097/00004630-198803000-00007.
Profound, irreversible ototoxicity has been reported following oral and topical neomycin therapy. Preexisting renal disease is a known risk factor for this adverse effect. In spite of the potential hazards of this drug, it continues to be used widely both orally and topically. This is a report of a severe, permanent hearing deficit that occurred in a patient with chronic renal failure. The patient, who had developed decubitus ulcers, was treated for three weeks with topical 1% neomycin solution applied in gauze-soaked bandages. Regular hemodialysis failed to prevent this adverse effect. Caution should be exercised in selecting patients to receive prolonged neomycin therapy.
口服和局部应用新霉素治疗后已报告有严重的、不可逆的耳毒性。预先存在的肾脏疾病是这种不良反应的已知危险因素。尽管该药存在潜在危害，但它仍在口服和局部广泛使用。本文报告了一名慢性肾衰竭患者发生的严重永久性听力丧失。该患者发生了压疮，用浸有1%新霉素溶液的纱布绷带进行局部治疗三周。定期血液透析未能预防这种不良反应。在选择接受长期新霉素治疗的患者时应谨慎。
