de Jong T P, Donckerwolcke R A, Boemers T M
Pediatric Renal Center, University Hospital for Children and Youth, Utrecht, The Netherlands.
J Urol. 1993 Oct;150(4):1199. doi: 10.1016/s0022-5347(17)35725-7.
Neomycin is known for its ototoxicity after many different methods of administration of the drug. Neomycin sometimes is used for bladder irrigation in patients with urinary tract infections when other treatments fail. To our knowledge toxicity after bladder instillation of neomycin has not been reported previously. We report a case of perception deafness in a boy with end stage renal disease who underwent neomycin bladder instillations following augmentation of the bladder with a megaureter.
新霉素在通过多种不同给药方式使用后，以其耳毒性而闻名。当其他治疗方法无效时，新霉素有时用于治疗尿路感染患者的膀胱冲洗。据我们所知，此前尚未有关于新霉素膀胱灌注后毒性反应的报道。我们报告了一例患有终末期肾病的男孩，在因巨输尿管行膀胱扩大术后接受新霉素膀胱灌注，出现感音性耳聋的病例。
