N-双（2-羟丙基）亚硝胺单次给药对大鼠的致癌作用。
Carcinogenic effect of N-bis(2-hydroxypropyl)nitrosamine by a single administration in rats.
作者信息
Konishi Y, Ikeda T, Yoshimura H, Kawabata A, Mikami R
出版信息
Cancer Lett. 1979 Feb;6(2):115-9. doi: 10.1016/s0304-3835(79)80009-9.
PMID:436111
Abstract
The carcinogenic effect of a single intraperitoneal injection of N-bis)2-hydroxypropyl)nitrosamine (BHP) was studied in male Wistar rats. Lung tumors (adenomas and adenocarcinomas) had the highest incidence (100%). Fewer neoplasms were induced in the thyroid (adenomas and adenocarcinomas, 36%), kidney (renal cell carcinomas, 8%), and the sigmoid colon (adenomas and adenocarcinomas, 9%). No pancreatic neoplasms were found.
摘要
研究了单次腹腔注射N-双（2-羟丙基）亚硝胺（BHP）对雄性Wistar大鼠的致癌作用。肺部肿瘤（腺瘤和腺癌）的发生率最高（100%）。甲状腺（腺瘤和腺癌，36%）、肾脏（肾细胞癌，8%）和乙状结肠（腺瘤和腺癌，9%）诱导产生的肿瘤较少。未发现胰腺肿瘤。
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