苯巴比妥和咔唑对经N-双（2-羟丙基）亚硝胺预处理的大鼠肺、甲状腺、肾脏和膀胱致癌作用的影响。
Effects of phenobarbital and carbazole on carcinogenesis of the lung, thyroid, kidney, and bladder of rats pretreated with N-bis(2-hydroxypropyl)nitrosamine.
作者信息
Shirai T, Masuda A, Imaida K, Ogiso T, Ito N
机构信息
First Department of Pathology, Nagoya City University Medical School.
出版信息
Jpn J Cancer Res. 1988 Apr;79(4):460-5. doi: 10.1111/j.1349-7006.1988.tb01614.x.
Abstract
Studies were made on potential modifying effects of phenobarbital (PB) and carbazole on tumor development induced by N-bis(2-hydroxypropyl)nitrosamine (DHPN), a wide-spectrum carcinogen in rats. Effects on the lung, thyroid, kidney, bladder and liver were investigated. Male F344 rats were given 0.2% DHPN in their drinking water for 1 week and then 0.05% PB or 0.6% carbazole in their diet for 50 weeks. Control animals were treated with either DHPN or PB or carbazole only. Neither PB nor carbazole affected the incidence or histology of lung tumors. However, PB promoted the development of thyroid tumors and preneoplastic lesions of the liver, while carbazole promoted the induction of renal pelvic tumors.
摘要
研究了苯巴比妥（PB）和咔唑对N-双（2-羟丙基）亚硝胺（DHPN，一种大鼠广谱致癌物）诱导的肿瘤发生的潜在修饰作用。研究了对肺、甲状腺、肾脏、膀胱和肝脏的影响。雄性F344大鼠在饮用水中给予0.2%的DHPN 1周，然后在饮食中给予0.05%的PB或0.6%的咔唑50周。对照动物仅用DHPN或PB或咔唑处理。PB和咔唑均未影响肺肿瘤的发生率或组织学。然而，PB促进了甲状腺肿瘤和肝脏癌前病变的发展，而咔唑促进了肾盂肿瘤的诱导。
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