Chen J, Yam L T, Janckila A J, Li C Y, Lam W K
Clin Chem. 1979 May;25(5):719-22.
Serum acid phosphatase activity in normal children (newborn to 18 years) is several fold that in normal adults. Activity is age-related but not sex-related. The isoenzyme pattern in children is similar to that in adults and contains no prostatic fraction. Quantitatively, most of the enzyme activity in the serum of children is tartrate-resistant and correlates well with heat-labile fractions of alkaline phosphatase activity in serum, suggesting that the source of the higher acid phosphatase activity in children is bone. Significant tartrate-resistant acid phosphatase activity was demonstrated in the giant cells in three patients with giant-cell tumors, but not in the "osteoblasts" in six patients with osteogenic sarcomas and many other normal or abnormal tissues. This work suggests that the higher enzyme activity in the serum of children represents a normal physiological phenomenon resulting from their greater osteoclastic activity.
正常儿童（从新生儿到18岁）血清酸性磷酸酶活性是正常成年人的几倍。该活性与年龄相关，但与性别无关。儿童的同工酶模式与成年人相似，且不包含前列腺部分。从数量上看，儿童血清中的大部分酶活性是抗酒石酸的，并且与血清中碱性磷酸酶活性的热不稳定部分密切相关，这表明儿童中较高的酸性磷酸酶活性来源是骨骼。在三名巨细胞瘤患者的巨细胞中证实了显著的抗酒石酸酸性磷酸酶活性，但在六名骨肉瘤患者的“成骨细胞”以及许多其他正常或异常组织中未发现。这项研究表明，儿童血清中较高的酶活性代表了一种由于其更大的破骨细胞活性而产生的正常生理现象。
