Urinary fibrinogen degradation products and differential protein clearances in renal disease.

The close correlation observed between urine concentration of fibrinogen degradation products and differential protein clearances in the proteinuria of renal disease has been confirmed. Heavy proteinuria in excess of 5 g/l however leads to raised FDP levels, irrespective of the selectivity of the protein clearance. A correction factor for proteinuria enables an accurate estimate of protein clearance from a single measurement of urine FDP.