Lagrue G, Hirbec G, Gouault-Heilmann M, Levent M, Branellec A, Moisy M
Pathol Biol (Paris). 1975 Jun;23(6):486-91.
Intravascular coagulation localized in glomeruli is of pathologic importance in human and experimental GN. The measure of fibrinogen related antigen (FRA) in serum and urine after concentration (Merskey's technique) was used to detect and estimate this phenomenon. In Rabbit Masugi GN, FRA were detected in urine 5 to 20 mg/24 h, in close correlation with the amount of proteinuria, the intesity of histological changes and the presence of fibrin deposits in glomeruli. In human GN, urine FRA were detected in many cases (0,5-10 mg/24 h) in correlation with the histological type of lesions (FRA + in primary or secondary proliferative GN) and with the evolutivity of disease (FRA + in cases with rapidly progressive kidney function deficiency). Urine FRA are also in correlation with intraglomerular fibrin deposits : this suggests that urine FRA originate from lysis of fibrin deposited within glomeruli. So urine FRA appears to be an indicator of type and severity of GN and probably of therapeutic measures, indicating anticoagulant and/or antithrombic therapy : the variations of urine FRA during treatment is of value to assess the effects of these drugs and to establish the prognosis of the disease.
肾小球内的血管内凝血在人类和实验性肾小球肾炎中具有病理重要性。采用浓缩后血清和尿液中纤维蛋白原相关抗原（FRA）的测定方法（Merskey技术）来检测和评估这一现象。在兔Masugi肾小球肾炎中，尿液中检测到FRA为5至20mg/24小时，与蛋白尿的量、组织学改变的强度以及肾小球中纤维蛋白沉积的存在密切相关。在人类肾小球肾炎中，许多病例（0.5 - 10mg/24小时）检测到尿液FRA，与病变的组织学类型（原发性或继发性增殖性肾小球肾炎中FRA阳性）以及疾病的演变（快速进行性肾功能不全病例中FRA阳性）相关。尿液FRA也与肾小球内纤维蛋白沉积相关：这表明尿液FRA源自肾小球内沉积纤维蛋白的溶解。因此，尿液FRA似乎是肾小球肾炎类型和严重程度的指标，可能也是治疗措施的指标，提示抗凝和/或抗血栓治疗：治疗期间尿液FRA的变化对于评估这些药物的效果和确定疾病预后具有价值。
