Elonen E, Neuvonen P J, Halmekoski J, Mattila M J
Clin Toxicol. 1979;14(1):79-85. doi: 10.3109/15563657909030116.
A 45-year-old man ate about 10 gm of dapsone (DDS). After initial vomiting marked methemoglobinemia with cyanosis, headache, and confusion developed. Methemoglobinemia subsided 7 days after ingestion when the concentrations of DDS and monoacetyldapsone (MADDS) were at the therapeutic level. Signs of hemolysis appeared on the third day after DDS ingestion, the hemolysis being maximal more than one week after ingestion. The initial disappearance of DDS and MADDS was slow, the apparent half-lives being 88 and 67 hr, respectively. Peroral activated charcoal seemed to shorten the half-lives of DDS and MADDS markedly. This result supports the concept of the enterohepatic cycle of dapsone and recommends the use of activated charcoal for several days in acute poisonings caused by DDS.
一名45岁男性摄入了约10克氨苯砜（DDS）。最初呕吐后，出现了明显的高铁血红蛋白血症，并伴有发绀、头痛和意识模糊。摄入后7天，当DDS和单乙酰氨苯砜（MADDS）浓度处于治疗水平时，高铁血红蛋白血症消退。氨苯砜摄入后第三天出现溶血迹象，摄入后一周多溶血最为严重。DDS和MADDS最初的消失速度较慢，表观半衰期分别为88小时和67小时。口服活性炭似乎能显著缩短DDS和MADDS的半衰期。这一结果支持了氨苯砜肠肝循环的概念，并建议在氨苯砜引起的急性中毒中连续数日使用活性炭。
