Larsen S O
Comput Programs Biomed. 1979 May;9(3):213-7. doi: 10.1016/0010-468x(79)90033-3.
Phenotypes in an ABO-like system of a number of genetically-independent persons from a number of populations are supposed to be observed. The program which is written in FORTRAN calculates maximum likelihood estimates of gene frequencies and their standard errors in each population and in the populations taken together. Furthermore the program calculates expected values and likelihood ratio and goodness of fit chi-square tests of Hardy-Weinberg equilibrium. If several subpopulations are pooled together a likelihood ratio test of homogeneity is performed.
假想要观察来自多个群体的许多基因独立个体在一个类ABO系统中的表型。用FORTRAN编写的程序计算每个群体以及合并在一起的群体中基因频率的最大似然估计值及其标准误差。此外，该程序还计算哈迪-温伯格平衡的期望值、似然比和拟合优度卡方检验。如果将几个亚群体合并在一起，则进行齐性似然比检验。
