甲状腺激素作用：在分离的细胞核和可溶性核提取物中对假定受体的体外证明。
Thyroid hormone action: in vitro demonstration of putative receptors in isolated nuclei and soluble nuclear extracts.
作者信息
Samuels H H, Tsai J S, Casanova J
出版信息
Science. 1974 Jun 14;184(4142):1188-91. doi: 10.1126/science.184.4142.1188.
PMID:4364362
Abstract
Saturable binding activities for triiodothyronine were demonstrated in vitro with isolated nuclei and soluble nuclear extracts of rat liver, kidney, and cultured GH(1) cells. The binding activity can be extracted from nuclei in soluble form with no significant change in hormone affinity and has properties of a nonhistone protein.
摘要
在体外，用大鼠肝脏、肾脏和培养的GH(1)细胞的分离细胞核及可溶性核提取物证实了三碘甲状腺原氨酸的饱和结合活性。该结合活性可以以可溶形式从细胞核中提取出来，激素亲和力无显著变化，并且具有非组蛋白的特性。
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