Wagner J C, Berry G, Skidmore J W, Timbrell V
Br J Cancer. 1974 Mar;29(3):252-69. doi: 10.1038/bjc.1974.65.
Two experiments in which SPF Wistar rats were exposed by inhalation to dust clouds of the UICC standard reference samples for periods of between one day and 2 years are described. All the samples of asbestos produced asbestosis which continued to progress after removal from exposure but only a little fibrosis was observed in control rats. Lung tumours, ranging in severity from adenomata to squamous carcinomata, were produced by all samples but in the controls there were only a few adenomata and none of the more serious tumours. Of the 20 tumours which metastasized, 16 occurred after exposure to one or other of the 2 chrysotile samples. In addition, a total of 11 mesotheliomata occurred, 4 of which were with crocidolite and 4 with Canadian chrysotile. Two of the mesotheliomata occurred with only one day's exposure to asbestos. There was a positive association between asbestosis and lung tumours.
描述了两项实验，在这些实验中，无特定病原体（SPF）的Wistar大鼠通过吸入国际抗癌联盟（UICC）标准参考样品的尘云暴露1天至2年。所有石棉样品均引发了石棉沉着病，在停止暴露后病情仍持续发展，但在对照大鼠中仅观察到少量纤维化。所有样品均引发了严重程度从腺瘤到鳞状癌的肺部肿瘤，但在对照大鼠中仅有少数腺瘤，没有更严重的肿瘤。在发生转移的20个肿瘤中，16个是在暴露于两种温石棉样品中的一种或另一种之后出现的。此外，总共发生了11例间皮瘤，其中4例与青石棉有关，4例与加拿大温石棉有关。有2例间皮瘤仅在接触石棉1天后就发生了。石棉沉着病与肺部肿瘤之间存在正相关。
