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Cholinergic augmentation of lymphocyte-mediated cytotoxicity. A study of the cholinergic receptor of cytotoxic T lymphocytes.淋巴细胞介导的细胞毒性的胆碱能增强作用。细胞毒性T淋巴细胞胆碱能受体的研究。
Proc Natl Acad Sci U S A. 1974 Apr;71(4):1330-3. doi: 10.1073/pnas.71.4.1330.
2
Nicotinic acetylcholine receptor on human lymphocytes.人类淋巴细胞上的烟碱型乙酰胆碱受体。
Ann N Y Acad Sci. 1981;377:427-35. doi: 10.1111/j.1749-6632.1981.tb33750.x.
3
Carbachol-induced theta-like activity in entorhinal cortex slices.卡巴胆碱诱导的内嗅皮层切片中的θ样活动。
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Biochemical characterization of the nicotinic cholinergic receptors in human brain: binding of (-)-[3H]nicotine.人脑中烟碱型胆碱能受体的生化特性：（-）-[3H]尼古丁的结合
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[Effect of cholinergic stimulation on spontaneous lymphocyte adhesion in vitro].[胆碱能刺激对体外自发性淋巴细胞黏附的影响]
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Functional shift from muscarinic to nicotinic cholinergic receptors involved in inositol trisphosphate and cyclic GMP accumulation during the primary culture of adrenal chromaffin cells.肾上腺嗜铬细胞原代培养过程中，参与三磷酸肌醇和环鸟苷酸积累的胆碱能受体从毒蕈碱型向烟碱型发生功能转变。
Biochem J. 1988 Apr 15;251(2):397-403. doi: 10.1042/bj2510397.
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The modulating influence of cyclic nucleotides upon lymphocyte-mediated cytotoxicity.环核苷酸对淋巴细胞介导的细胞毒性的调节作用。
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Cholinergic receptors in the Aplysia gill.海兔鳃中的胆碱能受体。
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Low-level exposure to methylmercury modifies muscarinic cholinergic receptor binding characteristics in rat brain and lymphocytes: physiologic implications and new opportunities in biologic monitoring.低水平接触甲基汞会改变大鼠大脑和淋巴细胞中毒蕈碱型胆碱能受体的结合特性：生理意义及生物监测中的新机遇。
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Carbamycholine modulation of E-rosette formation: identification of nicotinic acetylcholine receptors on a subpopulation of human T lymphocytes.卡巴胆碱对E玫瑰花结形成的调节作用：人T淋巴细胞亚群上烟碱型乙酰胆碱受体的鉴定
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Electrophysiology of T lymphocyte cholinergic receptors.T淋巴细胞胆碱能受体的电生理学
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Mast cell receptors controlling histamine release: influences on the mode of action of drugs used in the treatment of adverse drug reactions.控制组胺释放的肥大细胞受体：对用于治疗药物不良反应的药物作用模式的影响
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9
Parasympathetic innervation of the thymus: a histochemical and immunocytochemical study.胸腺的副交感神经支配：一项组织化学和免疫细胞化学研究。
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10
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本文引用的文献

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ISOLATION OF NEUROTOXINS FROM THE VENOM OF BUNGARUS MULTICINCTUS AND THEIR MODES OF NEUROMUSCULAR BLOCKING ACTION.从银环蛇毒液中分离神经毒素及其神经肌肉阻断作用方式
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An analysis of the direct and indirect actions of drugs on the isolated guinea-pig ileum.药物对离体豚鼠回肠的直接和间接作用分析。
Br J Pharmacol Chemother. 1963 Feb;20(1):150-70. doi: 10.1111/j.1476-5381.1963.tb01306.x.
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The action of tubocurarine and atropine on the normal and denervated rat diaphragm.筒箭毒碱和阿托品对正常及去神经大鼠膈肌的作用。
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Studies of allograft immunity in mice. II. Mechanism of target cell inactivation in vitro by sensitized lymphocytes.小鼠同种异体移植免疫研究。II. 致敏淋巴细胞在体外使靶细胞失活的机制。
Immunology. 1970 Apr;18(4):517-35.
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Use of a snake venom toxin to characterize the cholinergic receptor protein.使用蛇毒毒素来表征胆碱能受体蛋白。
Proc Natl Acad Sci U S A. 1970 Nov;67(3):1241-7. doi: 10.1073/pnas.67.3.1241.
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Elevation of guanosine 3',5'-cyclic phosphate in rat heart after perfusion with acetylcholine.乙酰胆碱灌注后大鼠心脏中环磷酸鸟苷的升高。
Proc Natl Acad Sci U S A. 1970 Jun;66(2):398-403. doi: 10.1073/pnas.66.2.398.
7
Acetylcholine receptor. I. Identification and biochemical characteristics of a cholinergic receptor of guinea pig cerebral cortex.乙酰胆碱受体。I. 豚鼠大脑皮层胆碱能受体的鉴定及生化特性
J Biol Chem. 1972 Jan 10;247(1):130-45.
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In vitro cytotoxic activity of thymus cells sensitized to alloantigens.对同种抗原致敏的胸腺细胞的体外细胞毒性活性。
Nature. 1970 Jul 4;227(5253):72-3. doi: 10.1038/227072a0.
9
Studies of allograft immunity in mice. I. Induction, development and in vitro assay of cellular immunity.小鼠同种异体移植免疫研究。I. 细胞免疫的诱导、发展及体外检测
Immunology. 1970 Apr;18(4):501-15.
10
Quantitative assay of the lytic action of immune lymphoid cells on 51-Cr-labelled allogeneic target cells in vitro; inhibition by isoantibody and by drugs.体外定量测定免疫淋巴细胞对51-铬标记的同种异体靶细胞的溶解作用；同种抗体和药物的抑制作用。
Immunology. 1968 Feb;14(2):181-96.

淋巴细胞介导的细胞毒性的胆碱能增强作用。细胞毒性T淋巴细胞胆碱能受体的研究。

Cholinergic augmentation of lymphocyte-mediated cytotoxicity. A study of the cholinergic receptor of cytotoxic T lymphocytes.

作者信息

Strom T B, Sytkowski A J, Carpenter C B, Merrill J P

出版信息

Proc Natl Acad Sci U S A. 1974 Apr;71(4):1330-3. doi: 10.1073/pnas.71.4.1330.

DOI:10.1073/pnas.71.4.1330
PMID:4364534
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC388221/
Abstract

Cholinergic agonists have previously been shown to augment the ability of sensitized lymphocytes to injure cells bearing the sensitizing alleantigens. The cholinergic receptor of the attacking lymphocyte population has been studied with pharmacological manipulation of an in vitro system that quantitates the injury mediated by sensitized attacking cells upon target cells. The data reveal that muscarinic ligands are several orders of magnitude more potent than nicotinic agents in altering cytotoxicity.

摘要

胆碱能激动剂此前已被证明可增强致敏淋巴细胞损伤携带致敏等位抗原细胞的能力。通过对体外系统进行药理学操作来研究攻击淋巴细胞群体的胆碱能受体，该系统可定量致敏攻击细胞对靶细胞介导的损伤。数据显示，在改变细胞毒性方面，毒蕈碱配体的效力比烟碱剂强几个数量级。