淋巴细胞介导的细胞毒性的胆碱能增强作用。细胞毒性T淋巴细胞胆碱能受体的研究。
Cholinergic augmentation of lymphocyte-mediated cytotoxicity. A study of the cholinergic receptor of cytotoxic T lymphocytes.
作者信息
Strom T B, Sytkowski A J, Carpenter C B, Merrill J P
出版信息
Proc Natl Acad Sci U S A. 1974 Apr;71(4):1330-3. doi: 10.1073/pnas.71.4.1330.
Abstract
Cholinergic agonists have previously been shown to augment the ability of sensitized lymphocytes to injure cells bearing the sensitizing alleantigens. The cholinergic receptor of the attacking lymphocyte population has been studied with pharmacological manipulation of an in vitro system that quantitates the injury mediated by sensitized attacking cells upon target cells. The data reveal that muscarinic ligands are several orders of magnitude more potent than nicotinic agents in altering cytotoxicity.
摘要
胆碱能激动剂此前已被证明可增强致敏淋巴细胞损伤携带致敏等位抗原细胞的能力。通过对体外系统进行药理学操作来研究攻击淋巴细胞群体的胆碱能受体，该系统可定量致敏攻击细胞对靶细胞介导的损伤。数据显示，在改变细胞毒性方面，毒蕈碱配体的效力比烟碱剂强几个数量级。
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