Pugge H R, Torrecilla A, Pellanda R J
Acta Gastroenterol Latinoam. 1979;9(3):159-63.
We have induced acute hepatitis in rats with the amino sugar Galactosamine by i.p. injection. The development of the disease was controlled by measurements of several metabolites and enzymes in serum, and light and electronic microscopy. Tyrosine transaminase was induced by i.p. injection of Cortisol, that increases ten times enzyme activity in liver parenchyma of normal rats. This inductive phenomenon cannot be observed in animals with galactosamine hepatitis. We discuss the probable mechanism and their relationship with some forms of viral hepatitis in human beings.
我们通过腹腔注射氨基糖半乳糖胺在大鼠中诱发了急性肝炎。通过测量血清中的几种代谢物和酶以及光镜和电镜观察来控制疾病的发展。腹腔注射皮质醇可诱导酪氨酸转氨酶，这会使正常大鼠肝实质中的酶活性增加十倍。在患有半乳糖胺肝炎的动物中无法观察到这种诱导现象。我们讨论了可能的机制及其与人类某些形式病毒性肝炎的关系。
