采用白细胞黏附抑制法对肝细胞癌进行特异性免疫诊断。
Specific immunodiagnosis of hepatocellular carcinoma by leucocyte adherence inhibition.
作者信息
Halliday W J, Halliday J W, Campbell C B, Maluish A E, Powell L W
出版信息
Br Med J. 1974 May 18;2(5915):349-52. doi: 10.1136/bmj.2.5915.349.
Abstract
The leucocyte adherence inhibition test provides a rapid, reliable, and specific technique for the immunodiagnosis of primary hepatocellular carcinoma (malignant hepatoma). The patient's blood leucocytes are tested in vitro for cell-mediated immunity against tumour-associated antigens and the serum is tested for blocking factor which interferes with the immunological reaction. Specific reactivity of both leucocytes and serum was consistently detected in patients with malignant hepatoma, and negative reactions were obtained in other liver diseases including secondary tumours of the liver. The test has provided positive evidence for the presence of hepatoma when more conventional methods gave doubtful or negative results. A positive result preceded the clinical appearance of tumour by up to three years in two patients.
摘要
白细胞黏附抑制试验为原发性肝细胞癌（恶性肝癌）的免疫诊断提供了一种快速、可靠且特异的技术。对患者的血液白细胞进行体外检测，以评估其针对肿瘤相关抗原的细胞介导免疫反应，并检测血清中干扰免疫反应的阻断因子。在恶性肝癌患者中始终能检测到白细胞和血清的特异性反应，而在包括肝转移瘤在内的其他肝病患者中则得到阴性反应。当更传统的方法得出可疑或阴性结果时，该试验为肝癌的存在提供了阳性证据。在两名患者中，阳性结果比肿瘤的临床出现提前了长达三年的时间。
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