白细胞黏附试验与白细胞游走抑制试验及对结核菌素纯蛋白衍生物皮肤反应性的比较。
Comparison of a leucocyte adherence test with the leucocyte migration inhibition test and skin reactivity to PPD.
作者信息
Bullen A W, Losowsky M S
出版信息
Clin Exp Immunol. 1978 Mar;31(3):408-13.
Using PPD as antigen, a leucocyte adherence test was compared with the leucocyte migration inhibition test and with the results of skin testing in healthy subjects. In the presence of antigen, leucocyte adherence was significantly greater in skin test-positive subjects than in skin test-negative subjects who had not previously had BCG vaccination. When the test was performed in heterologous serum, skin test-negative subjects who had had previous BCG vaccination showed significantly greater leucocyte adherence in the presence of antigen than skin test-negative subjects who had not had BCG vaccination; this difference was not present in autologous serum and its abolition was attributed to a serum blocking effect. The leucocyte adherence test correlated with the results of the leucocyte migration inhibition test in heterologous serum, and also with the results of skin testing interpreted in the light of previous vaccination history. The finding of increased rather than decreased adherence in the presence of antigen, although previously reported, is unusual.
以结核菌素纯蛋白衍生物（PPD）作为抗原，在健康受试者中，将白细胞黏附试验与白细胞游走抑制试验以及皮肤试验结果进行了比较。在有抗原存在的情况下，皮肤试验呈阳性的受试者的白细胞黏附明显高于未接种过卡介苗（BCG）的皮肤试验呈阴性的受试者。当在异种血清中进行该试验时，既往接种过卡介苗的皮肤试验呈阴性的受试者在有抗原存在时的白细胞黏附明显高于未接种过卡介苗的皮肤试验呈阴性的受试者；在自体血清中不存在这种差异，且这种差异的消除归因于血清阻断作用。白细胞黏附试验与异种血清中的白细胞游走抑制试验结果相关，也与根据既往接种史解释的皮肤试验结果相关。尽管之前有报道，但在有抗原存在时黏附增加而非减少这一发现并不常见。
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